DreamSkin® trials and data

DreamSkin® Health garments have been tested with groups of volunteers, and are currently undergoing further clinical trials with patients suffering from eczema and dermatitis.


The effectiveness of DreamSkin® Health garments at protecting the skin from external irritant damage

The ability of DreamSkin® Health garments to increase moisture recovery in damaged skin

The effectiveness of DreamSkin® Health garments at enhancing the recovery rate of damaged skin

Click one of the above to view the data


The effectiveness of DreamSkin® Health garments at protecting the skin from external irritant damage

Summary

DreamSkin® treated fabrics offer protection from external irritants. After 24 hours of artificial skin inflammation, skin covered with a DreamSkin® health fabric showed over 40% greater cells alive when compared to untreated fabric.

Methodology

The skin protection test of DreamSkin® textiles has been carried out utilising JIS L 1918 – Japanese Industrial Standard approved test for primary irritation tests.

Artificial skin pieces were covered with either DreamSkin® treated test fabrics or untreated fabrics.

Sodium Dodecyl Sulphate – a known irritant – was then dropped onto the test fabric and left to cure at 37 degrees centigrade for 24 hours.

Following removal of the test fabric, the artificial skin was then stained and analysed for live vs dead cells.

SDS containing Artificial sweat

V = (A1 – b) / (A2 – b) x 100

V: cell alive %
A1: sample light wave absorbency
A2: control light wave absorbency
b: extracted solution light wave absorbency

24 hours48 hours
PositiveV < 50-
Weakly positive50 ≤ V < 80V < 50
NegativeV ≥ 8 0-
Negative50 ≤ V < 80V ≥ 50

This test was repeated on five samples for each treatment. (20 total)

Cell Alive count was set as 100% for skin pieces which are not treated but follow the dyeing and extraction process. This sets a relative 100% as a baseline comparison and removes the analysis variable.

Results

The percentage of living cells is replicated below.

Water Content in Keratinized Layer (WCKL)

Statistical Analysis

Endpoint: the percentage of cells alive at 24 hours after being dropped with SDS.

(i) Summary

Totalmiss.minmaxmeans.d.median
Untreated50608973.010.4472
DreamSkin® 1509510398.43.2198
DreamSkin® 250107126112.87.85109
Control5099102100.21.1100

(ii) Analysis

Analysis of covarianceFdfp
Treatment30.543,16<0.0001

(iii) Pairwise comparisons of Treatments from ANCOVA model

Differences.e.95% CIp
Untreated - Control-27.204.27-36.25, -18.0<0.0001
DreamSkin® 1 - Control-1.804.27-10.85, 7.250.6789
DreamSkin® 2 - Control12.604.273.55, 21.650.0094
DreamSkin® 1 - Untreated25.404.2716.35, 34.45<0.0001
DreamSkin® 2 - Untreated39.804.2730.75, 48.85<0.0001
DreamSkin® 2 - DreamSkin® 114.404.275.35, 23.450.0039

Summary

The results of an analysis of covariance (ANCOVA) model shows that treatment has a significant impact on the fit of the model.

The individual pairwise comparisons demonstrate that both types of DreamSkin®  yield significantly higher percentage of cells alive than the untreated fabric.

Improvement for DreamSkin® 2 compared to an untreated fabric is in the order of 40% (95% CI: 31 – 49) more cells alive after 24 hours.


The ability of DreamSkin® Health garments to increase moisture recovery in damaged skin

Summary

The data shows a relative moisture recovery rate for DreamSkin® as 3 times that of untreated fabric and 1.6 times that of squalane treated fabric.

Test Methodology

Recovery of Trans-Epidermal water loss (TEWL) measures the rate that skin recovers water lost through irritation or skin complaints.

The methodology is presented clearly below, and was carried out on a test group of 15 volunteers – 5 in each test group.

Recovery of Transepidarmal Water Loss (TEWL) and Water Content in Keratinized Layer (WCKL)

1.
Measurement of TEWL and WCKL on normal Skin. (inside of forearm)

2.
Artificial inflammation using anionic surfactant (closed patch for 12hr)

3.
Measurement of TEWL and WCKL on rough Skin. (inside of forearm)

4.
Wearing of tights treated with DreamSkin® (6hr/day)

5.
Artificial inflammation using Measurement of TEWL and WCKL after wearing tights

6.
Steps 4 and 5 were repeated for 4 days continuously.

Then the TEWL index and the WCKL index were calculated

TEWL & WCKL

Results

Recovery of Trans-Edidermal Water Loss (TEWL)

Statistical Analysis

Analysis of Recovery rate of Trans-Epidermal Water Loss (TEWL)

Endpoint: the Area Under the Curve (AUC) for Recovery Rate over the 4 days following application of SDS on the skin.

(i) Summary

Totalmiss.minmaxmeans.d.median
Not Treated509.510.510.130.4210.3
Squalane5018.519.919.580.6119.85
DreamSkin®5028.7531.730.581.1530.95

(ii) Analysis

Analysis of convarianceFdfp
Treatment839.242,12<0.0001

(iii) Pairwise comparisons of Treatments from ANCOVA model

Differences.e.95% CIp
Squalane9.450.508.36, 10.54<0.0001
DreamSkin® - Not treated20.450.5019.36, 21.54<0.0001
DreamSkin® - Squalane11.000.509.91, 12.09<0.0001

Summary

The curve shows the pattern in each group, and includes a numerical summary of the AUC from which analysis is calculated.

The results of an analysis of covariance (ANCOVA) model shows that the DreamSkin® treatment has a significant impact on the rate TEWL recovery rate.

The three individual comparisons show that each pair of treatments is significantly different, with DreamSkin® giving a significantly higher cumulative recovery over the 4 days in comparison to either of the other groups.

In this sample, the data shows a relative recovery rate for DreamSkin® as 3 times that of untreated fabric and 1.6 times that of squalane treated fabric.


The effectiveness of DreamSkin® Health garments at enhancing the recovery rate of damaged skin

Summary

The test data shows a recovery rate for Dreamskin Health garments of approximately 3.3 times that of squalane treated fabric.

Test Methodology

Water Content in Keratinized Layer (WCKL) is a widely used measure of the state of health of skin – in cosmetics as well as dermatology.

The methodology is presented clearly below, and was carried out on a test group of 15 volunteers – 5 in each test group.

Fabrics treated with squalane were used as a comparison as it is a widely used emollient and cosmetic component.

Recovery of Transepidarmal Water Loss (TEWL) and Water Content in Keratinized Layer (WCKL)

1.
Measurement of TEWL and WCKL on normal Skin. (inside of forearm)

2.
Artificial inflammation using anionic surfactant (closed patch for 12hr)

3.
Measurement of TEWL and WCKL on rough Skin. (inside of forearm)

4.
Wearing of tights treated with DreamSkin® (6hr/day)

5.
Measurement of TEWL and WCKL after wearing tights

6.
Steps 4 and 5 were repeated for 4 days continuously.

Then the TEWL index and the WCKL index were calculated

TEWL & WCKL

Results

Water Content in Keratinized Layer (WCKL)

Analysis of Water Content in Keratinized Layer (WCKL)

Endpoint: the Area Under the Curve (AUC) for Recovery Rate over the 4 days following application of SDS on the skin.

(i) Summary

Totalmiss.minmaxmeans.d.median
Squalane500.986.253.4523.51
DreamSkin®508.8313.2411.511.6512.07

(ii) Analysis

Analysis of covarianceFdfp
Treatment48.351,80.0001

(iii) Pairwise comparisons of Treatments from ANCOVA model

Differences.e.95% CIp
DreamSkin® - Squalane8.061.165.39, 10.730.0001

Summary

The curve shows the pattern of WCKL recovery in each group, and includes a numerical summary of the AUC upon which the analysis is performed.

The comparison of the two groups shows a significant difference between the treatments, with DreamSkin® giving a significantly higher cumulative recovery over the 4 days in comparison to the squalane treated fabric.

The data suggests a recovery rate for DreamSkin® of approximately 3.3 times that of the squalane treated fabric.


How to Get DreamSkin®

DreamSkin® is a Class 1 medical device available on prescription from your healthcare professional, GP or Dermatologist.